"We cannot contain this threat. We must defeat it," Clinton said of the threat of terrorism. Watch video
TRENTON -- Hillary Clinton on Monday called on the U.S. to react to the Orlando mass shooting in a few ways: step up efforts to defeat the Islamic State, reach out to Muslims and ban assault weapons like the one used in Sunday's massacre.
"The murder of innocent people breaks our hearts, tears at our sense of security and makes us furious," the presumptive Democratic presidential nominee said during a speech in Cleveland. "Now we have to steel our resolve to respond."
A gunman killed 49 people and injured 53 others at a gay night club in Orlando, Fla., early Sunday morning -- the worst mass shooting in American history.
U.S. officials said the gunman, who was born in Queens, N.Y., pledged his allegiance to ISIS after he was apparently radicalized through the internet.
Clinton said U.S. and coalition forces have made strides fighting ISIS in Iraq and Syria but added she would seek to "stage more attacks." She also said she would boost efforts to root out "lone wolves" who have become radicalized either through the internet or travel to other countries.
"Orlando makes it even more clear," the former U.S. secretary of state said. "We cannot contain this threat. We must defeat it."
Trump renews calls for immigration ban
Clinton's speech stood in stark contrast to the one delivered by her opponent, presumptive Republican presidential nominee Donald Trump, who renewed his call for a ban on Muslims from entering the U.S. to guard against terrorism.
Though she didn't attack Trump by name, Clinton made a veiled reference to the Republican by saying America is "not a land of winners and losers" but instead "a country of we, not me."
She suggested the U.S. should be reaching out to Muslim communities, "not scapegoating or isolating them."
Clinton also said the U.S. should remove from the streets such "weapons of war" as the AR-15, which was used in Orlando and Sandy Hook Elementary School shooting in Connecticut in 2012.
And she called for Congress to once again pursue a law allowing people on the FBI's terrorist watch list to be banned from buying firearms. Democrats pushed for the law in the wake of the San Bernardino shootings last year, but the effort failed.
"If the FBI is watching you for suspected terrorist links, you shouldn't be able to just go buy a gun," Clinton said.
In addition, Clinton said the Orlando shooter targeted members of the LGBT community "out of hated and bigotry" and noted that "an attack on any American is an attack on all Americans."
But, she noted, LGBT voters " have millions of allies who will always have your back."
"And I am one of them," Clinton said.
Brent Johnson may be reached at bjohnson@njadvancemedia.com. Follow him on Twitter @johnsb01. Find NJ.com Politics on Facebook.